Selected Publications
Miwa, JM, Ibanez-Tallon, I, Crabtree, GW, Sanchez, R, Sali, A, Role, LW and Heintz, N (1999) lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Neuron 23, 105-114. PMCID:10402197. Cover and previewed manuscript
Ibanez-Tallon, I, Miwa, JM, Wang, HL, Adams, NC, Crabtree, GW, Sine, SM, and Heintz, N (2002) Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron 33, 893-903. PMID:11906696
Ibanez-Tallon, I, Wen, H, Miwa, JM, Xing, J, Tekinay, AB, Ono, F, Brehm, P, and Heintz, N (2004) Tethering Naturally Occurring Peptide Toxins for Cell-Autonomous Modulation of Ion Channel and Receptors in vivo. Neuron 41, 305-311. PMID:15294139.
Miwa, JM, Stevens, TR, King, SL, Calderone, BJ, Ibanez-Tallon, I, Xiao, C, Maki Fitzsimonds, R, Pavlides, C, Lester, HA, Picciotto, MR and Heintz, N (2006) The Prototoxin lynx1 acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival in vivo. Neuron 51, 587-600. PMID:16950157.
Tekinay, AB, Nong, Y, Miwa, JM, Lieberam, I, Ibanez-Tallon, I, Greengard, P, and Heintz, N. (2009) A role for LYNX2 in anxiety-related behavior. Proc. Natl. Acad. Sci. 106, 4477-4482. PMID:19246390. 2 citations. Click here for supplemental.
Morishita, H, Miwa, JM, Heintz, N, and Hensch, TK (2010) Lynx1, a cholinergic brake, limits plasticity in adult visual cortex. Science 330, 1238-40. PMID: 21071629 previewed manuscript
Miwa, JM, Freedman, R, and Lester, HA (2011) Neuronal circuits modulated by nicotinic receptors. Neuron, 70, 20-33. Review article, Featured review,PMID: 21482353
Miwa, JM, Lester, HA, and Walz, A (2012) Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction. Commissioned review, Physiology (Bethesda) 27, 187-99. PMID:22875450
Miwa, JM and Walz, A (2012) Enhancement in Motor Learning through Genetic Manipulation of the lynx1 Gene. PLoS ONE 7, e43302. doi:10.1371/journal.pone.0043302.
Kobayashi, A, Parker, RL, Wright, AP, Brahem, H, Ku, P, Oliver, KM, Walz, A, Lester, HA, and Miwa, JM (2014) lynx1 Supports Neuronal Health in the Mouse Dorsal Striatum During Aging: an Ultrastructural Investigation. J. Mol. Neurosci. 53, 525-36 PMID:25027556, doi: 10.1007/s12031-014-0352
Full Bibliography
Nichols, WA, Henderson, BJ, Yu, CY, Parker, RL, Richards, CL, Lester, HA, and Miwa, JM (2014) Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum. J. Biol. Chem. 289(45), 31423-32, PMID:25193667, pii: jbc.M114.573667
Lester, HA, Miwa, JM, and Srinivasan, R (2012) Psychiatric drugs bind to their classical targets within the early exocytotic pathway. Biol. Psychol., 72, 907-15. Review article PMID: 22771239
Drenan, RM, Grady, SR, Whiteaker, P, McClure-Begley, T, McKinney, S+, Miwa, JM, Bupp, S+, Heintz, N, McIntosh, JM, Bencherif, M, Marks, MJ, and Lester, HA. (2008) In vivo activation of midbrain dopamine neurons via sensitized, high-affinity α6 nicotinic acetylcholine receptors. Neuron 60, 123-136. PMID:18940593.
Lester, HA, Xiao, C, Srinivasan, R, Son, CD, Miwa, JM, Pantoja, R, Banghart, MR, Dougherty, DA, Goate, AM, and Wang, JC. (2009) Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery. AAPS, 11, 167-177. PMID:19280351
Drenan, RM, Grady, SR, Steele, AD, McKinney, S+, Patzlaff, NE, McIntosh, JM, Marks, MJ, Miwa, JM, and Lester, HA (2010) Cholinergic Modulation of Locomotion and Striatal Dopamine Release is Mediated by α6α4* Nicotinic Acetylcholine Receptors, J. Neurosci., 30, 9877-9889. PMID:20660270
Srinivasan,R, Pantoja, R, Moss, FJ, Mackey, EDW+, Son, CD, Miwa, JM, and Lester, HA (2010) Nicotine-induced α4β2 nicotinic receptor upregulation: Stoichiometry, β-subunit trafficking motifs, subcellular compartments and endoplasmic reticulum exit sites. J. Gen. Phys. 137, 59-79. PMID: 21187334. Cover manuscript
Richards, CI, Srinivasan, R, Xiao, C, Mackey, EDW+, Miwa, JM, and Lester, HA (2011) Trafficking of α4* nicotinic receptors revealed by superecliptic phluorin: effects of a β4 ALS-associated mutation and chronic exposure to nicotine. J. Biol. Chem. 286, 31241-9. PMID: 21768117
Srinivasan, R, Richards, CI, Mackey, EDW+, Rhee, DS+, Desphande, P, Miwa, JM and Lester, HA (2012) Nicotine remodels the endoplasmic reticulum through the Atf dependent pathway. Mol. Pharmacol. 81, 759-69. PMID: 22379121
Xiao, C, Miwa, JM, Wang, Y, Deshpande, P, and Lester, HA (2015) Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus. J. Neurosci., 35(9), 3734-3746, PMID:25740504 *Featured in “This Week in the Journal” at the Journal of Neuroscience, Theresa Esch.