Publications
Over 70 publications in peer reviewed international jourals and books (4,484 citations, h-index 35 as of September 2021). For a complete publication list see my profile in Google Scholar.
Levin, M., Spiro, R., Jain, H. and Falk, M.M. 2022. Effects of Titanium Implant Surface topology on Bone Cell Attachment and Proliferation in vitro Medical Devices: Evidence and Research 2022:15 103-119.
Hyland, C., Mfarej, M., Hiotis, G., Lancaster, S., Novak, N., Iovine, M.K., and Falk, M.M. 2021. Impaired Cx43 gap junction endocytosis causes morphological and functional defects in zebrafish. Mol Biol Cell Aug 11:mbcE20120797. Online ahead of print. PMID: 34379446.
Thamma, U., Kowal, T.J., Falk, M.M., and Jain, H. 2021. Nanostructure of bioactive glass affects bone cell attachment via protein restructuring upon adsorption. Sci Rep. 2021 Mar 11;11(1):5763. doi: 10.1038/s41598-021-85050-7. PMID: 33707489.
Liu, J., Chen, C.A., Zhu, X., Morrow, B.R., Thamma, U., Kowal, T.J., Moawad, H.M., Falk, M.M., Jain, H., and Huang, G.T. 2021. Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics – A preliminary assessment. J. Dent. Jun;109:103655.doi:10.1016 /j.jdent.2021.103655. PMID: 33798640.
Falk, M.M. 2020. Do CAR and CAR family members aid in gap junction formation? Bioessays. Dec;42(12):e2000276. doi: 10.1002/bies.202000276. PMID: 33145803.
Bhattacharya, S., Hyland, C., Falk, M.M., and Iovine, M.K. 2020. Connexin 43 gap junctional intercellular communication inhibits evx1 expression and joint formation in regenerating fins. Development Jul 3;147(13):dev190512. doi: 10.1242/dev.190512.
Thamma, U., Kowal, T.J., Falk, M.M., and Jain, H. 2019. Influence of nanoporosity on the nature of hydroxyapatite formed on bioactive calcium silicate model glass. J. Biomed. Mater. Res. B Appl. Biomater. May;107(4):886-899.
Kells-Andrews, R.M., Margraf, R.A., Fisher, C.G., and Falk, M.M. 2018. Connexin-43 K63-polyubiquitylation on lysines 264 and 303 regulates gap junction internalization. J. Cell Sci. 131(15):1-15.
Kowal, T.J., Hahn, N.C., Eider, S., Marzillier, J.Y., Fodera, D.M., Thamma, U., Jain, H., and Falk, M.M. 2018. New bioactive glass scaffolds with exceptional qualities for bone tissue regeneration: Response of osteoblasts and osteoclasts. Biomedical Materials, Jan 24; 13(2):025005. doi: 10.1088/1748-605X/aa9385. PMID: 29033393.
Thévenin, A.F., Margraf, R. A. Fisher, C. G., Kells-Andrews, R. M. and Falk, M.M. 2017. Phosphorylation regulates connexin43/ZO-1 binding and release, an important step in gap junction turnover. Molecular Biology of the Cell 28:3595-3608 PMID: 29021339.
Kowal, T.J., Golovchak, R., Chokshi, T., Harmes, J., Thamma, U., Jain, H., and Falk, M.M. 2017. Role of Phase Separation on the biological performance of 45S5 Bioglass®. J. Mater. Science: Mater. in Medicine 28:161.
Falk, M.M., Kowal, T.J., Almaida, R.M., Saad, M., Marei, M.K., Thamma, U., and Jain, H. 2016. Chapter 5: Sol-gel glass and nano-macro porous bioscaffolds, p. 105-135. In Bioactive Glasses: Fundamentals, Technology and Applications. R. Boccaccini, D. Brauer, L. Hupa (Eds). Publisher: Royal Society of Chemistry.
Falk, M.M., Fisher, C.G., Kells-Andrews, R.M., and Kowal, T.J. 2016. Chapter 2: Imaging gap junctions in living cells, p. 21-62. In Gap Junction Channels and Hemichannels, Methods in Signal Transduction. D. Bai and J. C. Saez (Eds.), CRC Press, Taylor & Francis Group.
Falk, M.M., Bell, C.L., Kells Andrews, R.M., and Murray, S.A. 2016. Formation, Trafficking and Processing of Annular Gap Junctions. BMC Cell Biology, 17 (Suppl. 1):22.
Kowal, T.J. and Falk, M.M. 2015. Primary cilia found on Hela and other cancer cells. Cell Biology International 39:1341-1347.
Nimlamool, W., Kells Andrews, R.M. and Falk, M.M. 2015. Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization. Molecular Biology of the Cell 26:276-55-2768.
Falk, M.M. 2015. Chapter 19: Autophagy degrades endocytosed gap junctions, p. 273-286. In Autophagy: Cancer, Other Pathologies, Inflammation, Infection, and Aging. Vol. 6, M. A. Hayat (Ed.), Academic Press, Elsevier.
Falk, M.M., Kells, R.M., Berthoud, V.M. 2014. Degradation of connexins and gap junctions. FEBS Letters 588:1221-1229.
Fong, J.T., Nimlamool, W., Falk, M.M. 2014. EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368. FEBS Letters 588:836-844.
Fong, J.T., Kells, R.M., Falk, M.M. 2013. Two tyrosine-based sorting signals in the Cx43 C-terminus cooperate to mediate gap junction endocytosis. Molecular Biology of the Cell 24:2834-2848.
Wang, S., Kowal, T.J., Marei, M.K, Falk, M.M., and Jain, H. 2013. Nanoporosity significantly enhances the biological performance of engineered glass scaffolds. Tissue Engineering Part A 19:1632-1640.
Thévenin, A.F. Kowal, T.J., Fong, J.T., Kells, R.M., Fisher, C.G., and Falk, M.M. 2013. Proteins and mechanisms regulating gap junction assembly, internalization and degradation. Physiology 28:93-116.
Baker, S.M, and Falk, M.M. 2012. Natural inflammatory mediators thrombin and endothelin modulate gap junction intercellular communication and cell-cell adhesion. eBook. Nova Science Publishers, Inc., Hauppauge, NY, USA (ISBN: 978-1-62417-375-2).
Falk, M.M., Fong, J.T., Kells, R.M., O'Laughlin, M.C., Kowal, T.J., Thévenin, A.F. 2012. Degradation of endocytosed gap junctions by autophagosomal and endo-/lysosomal pathways: a perspective. J. Membr. Biol. 245:465-76.
Fong, J.T., Kells, R.M., Gumpert, A.M., Marzillier, J.Y., Davidson, M.W. and Falk, M.M. 2012. Internalized gap junctions are degraded by autophagy. Autophagy 8:794-811. (Evaluated by ‘Faculty of 1000’)
Baker, S.M., and Falk, M.M. 2012. Chapter 18: Thrombin-mediated regulation of gap junction intercellular communication and cell-to-cell adhesion, pp. 247-254. In Thrombin: Function and Pathophysiology, Th. Stief (Ed.), Nova Science Publishers, Inc., Hauppauge, NY, USA (ISBN: 978-1-61942-087-8).
Jain, R.H., Marzillier, J.Y., Kowal, T.J., Wang, S., Jain, H., and Falk, M.M. 2011. Expression of mineralized tissue-associated proteins is highly upregulated in MC3T3-E1 osteoblasts grown on a borosilicate glass substrate. Advances in Bioceramics and Porous Ceramics IV: Ceramic Engineering & Science Proceedings, R. Narayan & P. Colombo (Eds.) vol. 32 (6):111-122.
Wang, S., Falk, M.M., Rashad, A., Saad, M.M., Marques, A.C., Almeida, R.M., Marei, M.K., and Jain, H. 2011. Evaluation of 3D nano-macro porous bioactive glass scaffold for hard tissue engineering. J. Mater. Sci: Mater. Med. 22:1195-1203.
Govindarajan, R., Chakraborty, S., Johnson, K.E., Falk, M.M., Wheelock, M.J., Johnson, K.R., and Mehta, P.P. 2010. Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells. Mol. Biol. Cell 21:4089-4107.
Vueva, Y., Gama, A., Almeida, R., Wang S., Jain, H., and Falk, M.M. 2010. Monolithic glass scaffolds with dual porosity prepared by polymer-induced phase separation and sol-gel. J. Americ. Ceramic Soc. 93(7):1945-1949.
Falk, M.M. 2010. Adherens junctions remain dynamic. BMC Biology 8:34-37.
Baker, S.M., R.W. Buckheit III, and Falk, M.M. 2010. Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes. BMC Cell Biology11:15-24. (Evaluated by ‘Faculty of 1000’) (highly accessed)
Chakraborty, S., S. Mitra, M.M. Falk, S. Caplan, M.J. Wheelock, K.R. Johnson; and P.M. Mehta. 2010. E-Cadherin Differentially Regulates the Assembly of Connexin43 and Connexin32 into Gap Junctions in Human Squamous Carcinoma Cells. J. Biol. Chem.285:10761-10776.
Jain, R.H., Wang, S., Moawad, H., Falk, M.M., Jain, H. 2010. Glass Bone Implants: The Effect of Surface Topology on Attachment and Proliferation of Osteoblast Cells on 45S Bioactive Glass. In Engineering Biomaterials for Regenerative Medicine; S. Bhatia, S. Bryant, J.A. Burdick, J.M. Karp, K. Walline (Eds.). Mater. Res. Soc. Symp. Proc. Vol. 1235, Warrendale, PA, 1235-RR03-47 (6 pages).
Marques, A., Almaida, R., Thima, A., Falk, M.M., Jain, H. 2009. Sol-gel derived glass scaffold with high pore interconnectivity and enhanced bioactivity. J. Materials Res., 24:3495-3502.
Moawad, H.M., Wang, S., Jain, H., Falk, M.M. 2009. Effect of zinc on bioactivity of nano-macroporous soda-lime phosphofluorosilicate glass-ceramics. Ceramic Engineering & Science Proceedings, Vol. 30, Issue 6, pp. 179-190.
Falk, M.M. S. Baker, A.M. Gumpert, D. Segretain, and R.W. Buckheit III. 2009. Gap junction turnover is achieved by the internalization of small endocytic double-membrane vesicles. Mol. Biol. Cell 20:3342-3352. (Evaluated by ‘Faculty of 1000’)
Gilleron, J., C. Fiorini, D. Carette, C. Avondet, M.M. Falk, D. Segretain, and G. Pointis. 2008. Molecular reorganization of Cx43, ZO-1, and c-Src interactions during HCH-induced internalization of gap junctions. J. Cell Sci. 121:4069-4078.
Baker, S.M., N. Kim, D. Segretain, and M.M. Falk. 2008. Acute internalization of gap junctions in vascular endothelial cells in response to inflammatory mediator-induced G-protein coupled receptor activation. FEBS Lett. 582:4039-4046 (Including Journal Issue Cover).
Gumpert, A.M., J.S. Varco, S.M. Baker, M. Piehl, and M.M. Falk. 2008. Double-membrane gap junction internalization requires the clathrin-mediated endocytic machinery. FEBS Lett. 582, 2887-2892.
Iovine, M.K., A.M. Gumpert, M.M. Falk, and T.C. Mendelsohn. 2008. Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels. FEBS Lett. 582:165-170.
Gilleron, J., D., Segretain, and M.M. Falk. 2007. Gap junction trafficking and regulation. Reactome: a curated knowledgebase of biological pathways. Cold Spring Harbor Laboratory, European Bioinformatics Institute, and GO Consortium.http://www.reactome.org
Piehl, M., C. Lehmann, A. Gumpert, J.-P. Denizot, D. Segretain, and M.M. Falk. 2007. Internalization of large double-membrane intercellular vesicles by a clathrin-dependent endocytic process. Mol. Biol. Cell 18:337-347. (Evaluated by ‘Faculty of 1000’)
Eastman, S. D., T. H. Chen, M. M. Falk, T. C. Mendelson, and M. K. Iovine. 2006. Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Genomics. 2006 Feb; 87(2):265-74.
Falk, M.M. 2005. Session 2: Connexin Binding Proteins. In: Laird, D. W. Overview of the 2005 International Gap Junction Conference. Published in Cell Communication and Adhesion, Vol. 6, Number 5, Dec. 2005.
Segretain, D, and M.M. Falk, 2004. Regulation of connexin biosynthesis, assembly, gap junction formation, and removal. Biochim. Biophys. Acta 1662, 3-21.
Lagrée, V., K. Brunschwig, P. Lopez, N. B. Gilula, G. Richard, and M.M. Falk. 2003. Specific amino acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43. J. Cell Science 116, 3189-3201.
Falk, M. M. 2002. Genetic tags for labelling live cells: gap junctions and beyond. Trends Cell Biol. 12:399-404.
Lauf, U., B.N.G. Giepmans, P. Lopez, S. Braconnot, S.-C. Chen, and M.M. Falk. 2002. Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells. Proc. Natl. Acad Sci. USA 99:10446-10451.
(On-Line Movies at: http://www.pnas.org/cgi/content/full/162055899/DC1)
Lopez, P., D. Balicki, L.K. Buehler, S.-C. Chen, and M.M. Falk. 2001. Distribution and dynamics of gap junction channels revealed in living cells. Cell Communication and Adhesion 8:237-242.
Falk, M. M. 2001. Connexins/Connexons: Cell-free expression. Methods Mol. Biol. 154:91-116.
Giepmans, B.N.G., I. Verlaan, T. Hengeveld, M.M. Falk, and W.H. Moolenaar. 2001. Gap junction protein connexin-43 interacts directly with microtubules. Current Biol. 11:1364-1368.
Shen, P., B.N.G. Giepmans, U. Lauf, and M.M. Falk. 2001. Assembly, structure and degradation of gap junctions in living cells. In: Beat Ludin and Andrew Matus (eds.) GFP in Motion II. Trends Cell Biol. 11:183 (CD-ROM Supplement).
Lauf, U., P. Lopez, and M.M. Falk. 2001. Expression of fluorescently tagged connexins: a novel approach to rescue function of oligomeric DsRed-tagged proteins. FEBS Lett. 498:11-15.
Falk, M.M. and U. Lauf. 2001. High-resolution fluorescence deconvolution microscopy and tagging with the autofluorescent tracers CFP, GFP, and YFP to study the structural composition of gap junctions in living cells. Microsc. Res. Tech. 52:251-262.
Falk, M. M. 2000. Cell-free synthesis for analyzing the membrane integration, oligomerization, and assembly characteristics of gap junction connexins. Methods 20:165-179.
Falk, M.M. 2000. Connexin-specific distribution within gap junctions revealed in living cells. J. Cell Sci. 113:4109-4120.
(On-Line Movies at: http://jcs.biologists.org/cgi/content/full/113/22/4109/DC1)
Falk, M.M. 2000. Biosynthesis and structural composition of gap junction intercellular membrane channels. Eur. J. Cell Biol. 79:564-574.
Falk, M. M. and N. B. Gilula. 1998. Connexin membrane protein biosynthesis is influenced by polypeptide positioning within the translocon and signal peptidase access. J. Biol. Chem. 273:7856-7864.
Falk, M.M., L.K. Buehler, N.M. Kumar, and N.B. Gilula. 1998. Cell-Free Expression of Functional Gap Junction Channels, p. 135-139. In R. Werner (ed.), Gap Junctions-1998. IOS Press, Amsterdam, The Netherlands.
Yeager, M., V. Unger, and M.M. Falk. 1998. Synthesis, Assembly, and Structure of Gap Junction Intercellular Channels. Curr. Opin. Struc. Biol. 8:517-524.
Kahn, T.W., R.N. Beachy, and M.M. Falk. 1997. Cell-free expression of a GFP fusion protein allows quantitation in vitro and in vivo. Current Biol. 7:R207-R208.
Falk, M.M., L.K. Buehler, N.M. Kumar, and N.B. Gilula. 1997. Cell-free Synthesis and Assembly of Connexins into Functional Gap Junction Membrane Channels. EMBO J. 16:2703-2716.
Falk, M.M., N.M. Kumar, and N.B. Gilula. 1995. Biosynthetic Membrane Integration of Connexin Proteins. Progress in Cell Research 4:319-322.
Falk, M.M., N.M. Kumar, and N.B. Gilula. 1994. Membrane Insertion of Gap Junction Connexins: Polytopic Channel Forming Membrane Proteins. J. Cell Biol. 127:343-355.
Falk, M.M., F. Sobrino, and E. Beck. 1992. VPg gene Amplification Correlates with Infective Particle Formation in Foot-and-Mouth Disease Virus. J. Virol. 66:2251-2260.
Falk, M.M. 1991, p. 34, Fig. 1.1.15, A. In P. Sitte, H. Ziegler, F. Ehrendorfer, and A. Bresinsky (eds.), Strasburger, Lehrbuch der Botanik, 33. Neubearbeitete Auflage-1991. Gustav Fischer Verlag, Stuttgart, Jena, New York.
Zibert, A., G. Maass, K. Strebel, M.M. Falk, and E. Beck. 1990. Infectious Foot-and-Mouth Disease Virus Derived from a Cloned Full-Length cDNA. J. Virol. 64:2467-2473.
Falk, M.M., P.R. Grigera, I.E. Bergmann, and E. Beck. 1990. Presumed Transcription Regulating Domain of Histone H3 is Cleaved Off During Infection by Foot-and-Mouth Disease Virus. Internat. J. Microbiol. Hygiene. 272:366-367.
Falk, M.M., P.R. Grigera, I.E. Bergmann, A. Zibert, and E. Beck. 1990. Viral Protease 3C-Mediated Cleavage of Histone H3 in Foot-and-Mouth Disease Virus-Infected Cells, p. 184-187. In M. A. Brinton and F. X. Heinz (eds.), -1990. American Society for Microbiology, Washington, DC, USA.
Falk, M.M., P.R. Grigera, I.E. Bergmann, A. Zibert, G. Multhaup, and E. Beck. 1990. Foot-and-Mouth Disease Virus Protease 3C Induces Specific Proteolytic Cleavage of Host Cell Histone H3. J. Virol. 64:748-756.
Mayer, T., T. Tamura, M.M. Falk, and H. Niemann. 1988. Membrane Integration and Intracellular Transport of the Coronavirus Glycoprotein E1, a Class III Membrane Glycoprotein. J. Biol. Chem. 263:14956-14963.